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Control of Risks in Work with Biological Agents
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Book : Control of Risks in Work with Biological Agents Author : * E.Radek Language : English Library : Health-Safety-Environment Publish Place : Germany ISBN : 92-843-1138-1 ISSN : 1015-8022 Volume : 2 Publish Date : January 2000 Publisher : The International Social Security Association (ISSA) Book Type : Book Book Number : 1247 |
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INDEX
Contents1. Introduction
2. Biological agents and their risks to humans
2.1 Biological agents
2.2 Infectivity
2.3 Pathogenicity and virulence
2.4 Ability to form toxins
2.5 Allergenicity
3. Transmission of infectious agents - chain of transmission and reservoirs
4. Defence against infection
4.1 Immunological defences
4.1.1 Immune status
4.1.2 General state of health
4.2 Immunity and vaccination
5. Assessment of risks before the use of biological agents
5.1 Risk Group 1
5.2 Risk Group 2
5.3 Risk Group 3
5.4 Risk Group 4
6. Dispersal mechanisms
6.1 The air-borne route
6.1.1 Aerosols
6.1.2 Mechanisms of aerosol formation
6.2 Dispersion by human agency
7. Safety in the laboratory
7.1 General principles concerning the control of risks
7.2 Laboratory equipment
7.3 Some general rules concerning laboratory work
7.4 Working with biological agents at Containment Level 1: General rules applicable to the use of biological agents
7.5 Working with biological agents at Containment Level 2
7.6 Working with biological agents at Containment Level 3
7.7 Working with biological agents at Containment Level 4
8. Safe use of laboratory equipment
8.1 Centrifuges
8.2 Autoclaves
8.3 Equipment for cell disruption
8.4 Blenders (Vortex mixers, shakers)
8.5 Fermenters and other apparatus
9. Microbiological safety cabinets (MSCs)
9.1 Classification of MSCs
9.2 General guidelines for class 1. 2 and 3 MSCs
9.3 Additional guidelines for class 1 and 2 MSCs
9.4 Additional special guidelines for class 2 MSCs
9.5 Additional guidelines for class 3 MSCs
9.6 Testing MSCs
10. Disinfection and sterilisation
10.1 Physical methods
10.1.1 Moist heat
10.1.2 Dry heat
10.1.3 Filter sterilisation of gases and liquids
10.1.4 Ultraviolet radiation (UV)
10.2 Chemical methods
10.2.1 Overview and criteria for choice
10.2.2 Examples of common disinfectants
10.2.3 Precautions in the use of chemical disinfectants
11. Cleaning laboratories and hygiene protocol
11.1 Cleaning laboratories
11.2 Hygiene protocol
12. Monitoring of cleaning and disinfection measures (biocontrol programme)
12.1 Surfaces
12.2 Air quality control
13. Chemical risks
13.1 Types of risks
13.2 Some general guidelines
13.3 Examples of dangerous chemical substances
14. Other risks
14.1 Fire and explosion
14.2 Mechanical risks
14.3 Pressurised gas cylinders
14.4 Electricity
14.5 Burns and scalds
14.6 Cryogenic substances
14.6.1 Liquid nitrogen
14.6.2 Dry ice (solid CO2)
14.7 Risks at work with lasers
14.8 Ultraviolet radiation (UV)
14.9 Radioactivity 14.10 Ultrasonics
15. Emergency measures
16. Occupational health surveillance
17. Check list befor commencing work with biological agents
Annex: Cell cultures Further literature
