Control of Risks in Work with Biological Agents
INDEXContents10 1. Introduction 2. Safe work in production 13 3. Biotechnology installation 4. Fermentation 4.1 Inoculation 4.2 Sampling 4.3 Aeration 4.4 Exhaust gas 4.5 Foam suppression 5. Harvesting 6. Recovery and purification 7. Technical equipment 7.1 Constructional features 7.2 Seals 7.2.1 Seals with static action 7.2.2 Seals with dynamic action 7.3 Agitator drives 7.4 Material transport 7.5 Valves 7.6 Venting systems 7.7 Connecting elements 7.8 Steam seals 7.9 Sterile filters 7.9.1 Sterile filtration of the supply air and exhaust gas 7.9.2 Changing the exhaust gas filter cartridge 7.9.3 Filter test methods 7.9.4 Sterile filtration of 5 liquid media 7.10 Measuring instruments 5 for process monitoring 7.10.1 Probes 7.10.2 Pressure gauges 7.10.3 Temperature sensors 7.10.4 Flowmeters 12. Occupational health surveillance 7.10.5 Weight measurement, 59 liquid level measure- 13. Emergency measurement 7.10.6 Exhaust gas measurement 59 14. Glossary 60 8. Inactivation 61 8.1 Disinfection 62 8.2 Sterilisation 63 9. Disposal 10. Secondary containment 11. Organisational and personal protection measures 11.1 Organisation 11.1.1 Guide for the preparation of operating instructions 11.2 Hygiene 11.3 Personal protection equipment
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