Male Contraception Advances and Future Prospects
INDEXCONTENTS OVERVIEW 1. Male Contraception in Family Planning Programs D. Malcolm Potts 2. The International Experience with Vasectomy Douglas H. Huber, Sawon Hong, John A. Ross 3. Discussion Summary: Overview Moderator: John J. Sciarra VASECTOMY AND REVERSAL: CLINICAL ISSUES 4. Epidemiologic Studies of Vasectomy Diana B. Petitti 5. Psychosocial Consequences of Vasectomy in Developed and Developing Countries Rochelle N. Shain 6. Microsurgery for Vasectomy Reversal and Vasoepididymostomy Sherman J. Silber 7. Discussion: Vasectomy and Reversal: Clinical Issues Moderator: Alfredo Goldsmith MALE REPRODUCTIVE PHYSIOLOGY AND CONTRACEPTION 8. Sites for Disruption of Male Fertility Nancy J. Alexander 9. Endocrine Control of Human Spermatogenesis: Possible Mechanisms for Contraception William J. Bremner, Alvin M. Matsumoto 10. Sperm Maturation and the Potential for Contraceptive Interference William Christopher Liberty Ford, Geoffrey M. H. Waites xii I Male Contraception: Advances and Future Prospects 11. Discussion: Male Reproductive Physiology and Contraception Moderator: R. John Aitken ASSESSMENT OF SPERM FUNCTION 12. Semen Analysis as a Tool in the Search for a Male Contraceptive Rune Eliasson 13. Longitudinal Studies of Semen Measures in Normal Men Marilyn L. Poland, Kamran S. Moghissi, Paul T. Giblin, Joel W. Ager, Jane M. Olson 14. Sperm-Mucus Interaction and Cervical Mucus Penetration Test Erik Odeblad 15. Predictive Value of In Vitro Sperm Function Tests R. John Aitken, Stewart Irvine, Jane S. Clarkson, David William Richardson 16. Discussion: Assessment of Sperm Function Moderator: Emil Steinberger EXPERIMENTAL APPROACHES FOR MALE CONTRACEPTION 17. Experimental Studies in the Development of Male Contraceptives Andrzej Bartke, Do Won Hahn, Robin G. Foldesy, John L. McGuire 18. Toxicology and Mechanism of Action of Cossypol Donald P. Waller, Xin-yi Niu, Inchull Kim 19. Development of a New Reversible Vas Deferens Occlusion Device Lourens J. D. Zaneveld, James W. Burns, Stan A. Beyler, William A. Depel, Seymour W. Shapiro Contents 20. Capacitation and Fertilization: Acrosin Inhibitors (Aryl 4-Guanidinobenzoates) As Vaginal Contraceptives Lourens J. D. Zaneveld, Joanne Kaminski, Donald P. Waller, Ludwig Bauer 21. Prototype of a New Long-Acting Spermistatic Agent Do Won Hahn, John L. McGuire 22. Sulfasalazine as a Male Contraceptive Agent David R. White, R. John Aitken 23. Tolnidamine in Male Contraception: A Survey of Preclinical Data Patrizio Scorza Barcellona, Valeria Cioli, Cesare De Martina, C. Wayne Bardin, Irving M. Spitz 24. Prospects of a Male Contraceptive Based on the Selective Antispermatogenic Action of 1,2,3-Trihydroxypropane (THP, Glycerol) John P. Wiebe, Kevin J. Barr, Kevin D. Buckingham, P. Douglas Geddes, Patricia A. Kudo 25. Toward a Same-Day, Orally Administered Male Contraceptive Brian H. Vickery, Martha B. Grigg, Jessie C. Goodpasture, Karen K. Bergstrom, Keith A. M. Walker 26. Discussion: Experimental Approaches for Male Contraception Moderators: C. Alvin Paulsen, Jeffrey M. Spieler HORMONAL APPROACHES 27. Androgen-Progestogen Combinations C. Alvin Paulsen 28. Testosterone-Estradiol Contraception in the Male Rhesus Monkey Larry L. Ewing 29. 19-Nortestosterone for Male Fertility Regulation Ulrich A. Knuth, Hermann Behre, Lutz Belkien, Hinrich Bents, Eberhard Nieschlag xiv I Male Contraception: Advances and Future Prospects 30. Dissociating Antifertility Effects of a GnRH Antagonist from Its Adverse Effects on Mating Behavior: The Critical Importance of Testosterone Dose Shalender Bhasin, Thomas J. Fielder, Ronald S. Swerdloff 31. Overview of Controlled Release Systems for Male Contraception Danny H. Lewis, Thomas R. Tice, Lee R. Beck 32. Preliminary Results on the Effects of Testosterone Microcapsules Ricardo H. Asch, Teri 0. Heitman, Richard M. Gilley, Thomas R. Tice 33. Preclinical Studies with LHRH Antagonists Eric C. Petrie, Alvin M. Matsumoto, John J. Nestor, Jr., Brian H. Vickery, Kenneth M. Gross, Molly B. Southworth, William J. Bremner 34. Preclinical and Clinical Trials with LHRH Agonists and Antagonists Eberhard Nieschlag, Erik Michel, Gerhard F. Weinbauer 35. Discussion: Hormonal Approaches Moderators: Andrzej Bartke, Eberhard Nieschlag IMMUNOLOGIC APPROACHES 36. Immunopathologic Consideration of Antifertility Vaccine Kenneth S. K. Tung 37. Reasons for Abandoning Immunization Against FSH As an Approach to Male Fertility Regulation Eberhard Nieschlag 38. Partial Purification of Inhibin from Ovine Rete Testis Fluid Jean Rivier, Richard McClintock, Joan Vaughan, Gayle Yamamoto, Harry Anderson, Joachim Spiess, Wylie Vale, JosefVoglmayr, C. Yan Cheng, C. Wayne Bardin 39. Inhibin and Gonadal Parahormones: Possible Contraceptive Agents Paul Franchimont 40. Immunogenetic Considerations in the Development of Contraceptive Vaccines Based on Testicular or Sperm Antigens Deborah J. Anderson 41. Contraceptive Potential of Antisperm Antibodies Nancy J. Alexander 42. Immunologic Properties of LDH-C4 for Contraceptive Vaccine Development Erwin Goldberg, Joyce A. Shelton 43. Discussion: Immunologic Approaches Moderators: Nancy J. Alexander, Kenneth S. K. Tung Contributing Authors Workshop Participants Index
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